CPGs. Their model shows that cell-type-specific connectivity and a dominant inhibitory drive could underlie rhythm generation. Excitatory input could act to enhance the frequency range of these ...

In this important study, the authors conducted atomistic molecular dynamics simulations to probe the interactions between IRE and unfolded peptides. The results help reconcile contradicting ...

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States ...

This study presents compelling evidence that the denitrosylase SCoR2 regulates cardioprotective metabolic reprogramming in the heart following ischemia/reperfusion injury. The findings are supported ...

This study provides useful information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis. In addition, the impact of Lamin A/C knockdown on telomere dynamics is explored ...

These fundamental findings offer a novel mechanism by which rubrerythrin tubules encapsulate encapsulin to prevent oxidative stress in Pyrococcus furiosus. However, there are a few reasonable concerns ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

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Researchers have used high-throughput neutralisation assays to reveal how gaps in individual immunity shape the success of circulating flu strains.

The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.

Using cryo-electron microscopy (cryo-EM) we determined a structure of mPiezo1 to an overall resolution of 3.7 Å (Figure 2 and Figure 2—figure supplement 1).Viewed down its 3-fold axis, the trimeric ...

Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.