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张力驱动肝星状细胞定向迁移协同调控肝纤维化进程的机制研究
来自国内的研究人员通过构建微加工体外模型,揭示了肝星状细胞(HSCs)在胶原基质中通过张力感知和液-液相分离(LLPS)介导定向迁移,从而协调肝纤维化特征性定向纤维隔(septa)形成的机制。该研究首次实现肝小叶六边形结构与人鼠HSCs动态行为的同步模拟 ...
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