CPGs. Their model shows that cell-type-specific connectivity and a dominant inhibitory drive could underlie rhythm generation. Excitatory input could act to enhance the frequency range of these ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States ...

The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

This study provides useful information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis. In addition, the impact of Lamin A/C knockdown on telomere dynamics is explored ...

This study presents compelling evidence that the denitrosylase SCoR2 regulates cardioprotective metabolic reprogramming in the heart following ischemia/reperfusion injury. The findings are supported ...

This study introduces a novel and broadly applicable metric-phenological lag-to partition the effects of spring warming from other abiotic constraints on plant phenology. While the dataset is ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Projection-specific optogenetic and chemogenetic experiments reveal a hippocampal-lateral septal pathway that potentially acts via the ventral tegmental area to regulate social novelty preference ...

Abstract Maize originated from teosinte parviglumis following a subspeciation event occurred in volcanic regions of Mesoamerica. The elucidation of the phenotypic changes that gave rise to maize have ...

Researchers have used high-throughput neutralisation assays to reveal how gaps in individual immunity shape the success of circulating flu strains.

This study presents significant and novel insights into the roles of zinc in mammalian meiosis/fertilization events. These findings are useful to our understanding of these processes. The evidence ...